# Resources & Training ## expand\_more ### Preparations and Considerations expand\_more - Laboratory Animal - [PREPARE Guidelines for Planning Animal Research and Testing](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/prepare_guidelines.pdf) - As part of ongoing efforts to reduce waste, promote animal alternatives, and increase the reproducibility of research and testing, a group of experts from the UK and Norway, led by Norecopa, has produced a set of guidelines and checklist for planning experiments. The checklist should be adapted to suit specific needs, for example in field research. Advice on use of the checklist is available on the Norecopa [website](https://norecopa.no/PREPARE). - [ARRIVE Guidelines](https://arriveguidelines.org/arrive-guidelines) - NIH is encouraging award recipients to include the *ARRIVE Essential 10 Checklist* in all NIH-supported publications describing vertebrate animal and cephalopod research. ### Justifying Animal Numbers expand\_more - Journal of Pharmacology and Pharmacotherapeutics - [How to Calculate Sample Size](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826013/?report=printable) - ILAR Journal - [Sample Size Determination](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275906/) - Lab Animal - [Fermi Approximation](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/lab_animal_48_9_249-253.pdf) - AALAS Webinar - [Right Numbers for Animal Protocols](https://www.aalas.org/store/detail?productId=9425188) ### Literature Search for Alternatives to Painful/Distressful Animal Procedures expand\_more - IACUC Policy - [Search for Alternatives](https://hu.sharepoint.com/sites/IACUCWiki/Shared%20Documents/Search%20for%20Alternatives.pdf) - OLAW Webinar - [Meeting Requirements for Alternatives Searches](https://olaw.nih.gov/education/educational-resources/webinar-2014-06-26.htm) - [TBASE](http://www.informatics.jax.org/mgihome/other/phenoallele_commun_resource.shtml) - A computerized database for transgenic animals and targeted mutations. - OLAW Webinar - [Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information](https://olaw.nih.gov/education/educational-resources/webinar-2021-12-09.htm) ### Pain Management in Rodent Animal Research expand\_more - HCCM [Resources](/services#hccm) - [Rodent "Body Condition" Scoring](https://hccm.med.harvard.edu/veterinary-services) - [Mouse Grimace Scale](https://hccm.med.harvard.edu/sites/g/files/omnuum3031/files/hccm/files/facial_expressions_of_pain_mouse.pdf) - [Rat Grimace Scale](https://hccm.med.harvard.edu/sites/g/files/omnuum3031/files/hccm/files/rat_grimace.pdf) - Nature Protocols - [OBSERVE: Guidelines for the Refinement of Rodent Cancer Models]() - Comparative Medicine - This issue of Comparative Medicine is devoted to pain as a clinical factor and experimental variable in laboratory rodents – covering ethical considerations regarding analgesia and pain management, the importance of pain recognition and management, sex and strain differences in response to pain and analgesics in mice, as well as the impact of pain on different models involving laboratory mice and rats. - [Pain as Clinical Factor and Experimental Variable](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_as_clinical_factor_and_experimental_variable.pdf) - [Ethics and IACUC Considerations on Analgesia](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/ethics_and_iacuc_considerations_on_analgesia.pdf) - [Review of Pain Assessment Methods](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/review_of_pain_assessment_methods.pdf) - [Clinical Management of Pain](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/clinical_management_of_pain.pdf) - [Strain and Sex Differences Response to Pain](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/strain_and_sex_differences_response_to_pain.pdf) - [Pain and Cancer Model](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_and_cancer_models.pdf) - [Pain and TBI and Stroke](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_and_tbi_and_stroke.pdf) - [Pain and Immune System and Inflammation](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_and_immune_system_and_inflammation.pdf) - [Pain and Orthopedic and Wound Healing Models](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_and_orthopedic_and_wound_healing_models.pdf) - [Pain and Sepsis](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/pain_and_sepsis.pdf) - [Study of Pain, Rats, and Mice](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/study_of_pain_rats_and_mice.pdf) - [Sleep, Pain, and Analgesics](https://iacuc.hms.harvard.edu/sites/g/files/omnuum2836/files/hma-iacuc/files/sleep_pain_and_analgesics.pdf) ### Monitoring for Humane Endpoints in Animal Research expand\_more - OOTI Guide - [Monitoring and Appropriate Humane Endpoints](https://hu.sharepoint.com/sites/IACUCWiki/Shared%20Documents/H.%20Monitoring%20and%20Appropriate%20Humane%20Endpoints.pdf) - OLAW Webinar - [Developing an Appropriate Strategy](https://olaw.nih.gov/education/educational-resources/webinar-2018-09-20.htm) ### Contingency Planning & Disaster Response expand\_more - HMS Guide - [Lab-Level Emergency Response](https://hu.sharepoint.com/sites/IACUCWiki/Shared%20Documents/Lab-Level%20Emergency%20Response%20Guide.pdf) fact\_check [### IACUC Training Requirements ](/training)Learn more about the IACUC training requirements for the Harvard Longwood Campus. handshake [### HCCM Hands-On Training ](/services#hccm)You can also request training with HCCM on specific procedures or research activities. policy [### IACUC Policies ](/policies)Visit the IACUC Wiki to learn about the institutional policies for the Harvard Longwood Campus. assured\_workload [### Lab Inspection Checklist ](https://iacuc.hms.harvard.edu/lab-inspection-checklist)Learn more about the routine inspection process.