This page is intended to help investigators plan animal experiments and understand the basic requirements surrounding animal research.
Visit the Wiki page to view IACUC policies, guidelines, and SOPs.
Resources & Training
Preparations and Considerations
- PREPARE guidelines (Laboratory Animal)
Justifying Animal Numbers
- How to calculate sample size (Journal of Pharmacology and Pharmacotherapeutics)
- Sample size determination (ILAR Journal)
- Power and sample size
- Fermi approximation (Lab Animal)
- Right numbers for animal protocols (AALAS webinar - $)
Literature Search for Alternatives to Painful/Distressful Animal Procedures
- Search for alternatives
- Meeting requirements for alternatives searches (OLAW webinar)
- TBASE: a computerized database for transgenic animals and targeted mutations
Pain Management in Rodent Animal Research
- Comparative Medicine 2019; Vol 69(6)
- Detecting and evaluating signs of pain in animals
- Rodent "body condition" scoring
- Mouse grimace scale
- Rat grimace scale
Monitoring for Humane Endpoints in Animal Research
Contingencies
Training Requirements for Working with Animals
| Use this guide to help facilitate the IACUC onboarding process. |
Guidance
| Learn how to access and complete training in HTP. | |
| For lab managers: Learn how to assign and monitor training in HTP. | |
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For lab managers: Use this spreadsheet to document and keep track of training for your staff. |
Additional Training?
The Harvard Center for Comparative Medicine provides hands-on training and additional resource materials.