Update to HCCM mouse analgesia formulary

January 18, 2022

HCCM has recently updated the analgesia formulary for mice. Changes include:

  • Buprenoprhine HCl: frequency of administration INCREASED from q-8-12 to q4-6
  • BupSR: added to the table, everyone is encouraged to use this over the non-SR formulation
  • Meloxicam: increased dose and frequency recommended – previously 5mg/kg q24, now 5-10 mg/kg q12-24
  • Ketoprofen: increased dose range and now have 24h dose option– previously 5mg/kg q12, now recommended as either 5-10mg/q12 or 20mg/kg q24
  • Removed ibuprofen, acetaminophen as recommended analgesic options

Please see the HCCM website for all recommended analgesia and anesthesia regimens. If you have any questions or concerns about the new regimens, please reach out to hccm@hms.harvard.edu. If your animal protocol is affected by these updates, your Protocol Liaison will help you update your protocol upon your next amendment or three-year renewal submission.